反应详情

Prepared according to Method M (Example 206) using (4-aminopyridin-2-yl)[1-(2-{[tert-butyl(dimethyl)silyl]oxy}-1,1-dimethylethyl)-1H-pyrrolo[3,2-c]pyridin-3-yl]methanone (Preparation 27) and 3-trifluoromethylphenylacetic acid at 70° C. The residue was purified over neutral alumina eluting with 50%-60% EtOAc in hexane followed by acid deprotection using 10% HCl in dioxane at room temperature for 18 hours. The reaction was concentrated in vacuo and purified using preparative HPLC to afford the title compound.

1. customPrepared
2. customat 70° C
3. customThe residue was purified over neutral alumina eluting with 50%-60% EtOAc in hexane
4. customat room temperature
5. customfor 18 hours
6. concentrationThe reaction was concentrated in vacuo
7. custompurified