反应详情

To (4-Chloro-benzyl)-5-[hydroxy-(1H-pyrrolo[2,3-b]pyridin-3-yl)-methyl]-6-methoxy-pyridin-2-yl-carbamic acid tert-butyl ester (68, 40.0 mg, 0.081 mmol) in acetonitrile (10.0 mL) were added trifluoroacetic acid (0.30 mL, 0.0039 mol) and triethylsilane (0.60 mL, 0.0038 mol). The reaction was heated to reflux for 3 hours. The reaction was concentrated to remove the solvents, then purified with silica gel column chromatography eluting with 40% ethyl acetate in hexane to give compound (P-0081, 10 mg, 32.7%). MS (ESI) [M+H+]+=379.4.

1. temperatureThe reaction was heated
2. temperatureto reflux for 3 hours
3. concentrationThe reaction was concentrated
4. customto remove the solvents
5. custompurified with silica gel column chromatography
6. washeluting with 40% ethyl acetate in hexane
7. customto give compound (P-0081, 10 mg, 32.7%)