反应详情

温度

80 °C

To 2,3,4-trihydroxybenzophenone (1.60 g, 6.95 mmol) was added DMF (30 ml), 1-bromooctadecane (7.3 g, 21.9 mmol) and potassium carbonate (4.32 g, 31.3 mmol), and the mixture was stirred at 80° C. overnight. The reaction mixture was cooled to room temperature, chloroform (100 ml) was added, and 1N hydrochloric acid (30 ml) was further added dropwise. After stirring, the mixture was partitioned, and the organic layer was washed with 1N hydrochloric acid (30 ml) and water (30 ml). The organic layer was evaporated under reduced pressure, and the residue was washed with methanol (30 ml). The obtained precipitate was slurry washed with methanol (45 ml) to give 2,3,4-trioctadecanoxybenzophenone (6.35 g, 6.43 mmol, yield 93%).

1. temperatureThe reaction mixture was cooled to room temperature
2. stirringAfter stirring
3. customthe mixture was partitioned
4. washthe organic layer was washed with 1N hydrochloric acid (30 ml) and water (30 ml)
5. customThe organic layer was evaporated under reduced pressure
6. washthe residue was washed with methanol (30 ml)
7. washwashed with methanol (45 ml)