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HRID1755896

反应详情

EQUATION

反应方程式

HRID 1755896 的结构方程式

REACTANTS

反应物

2
结构：CC(C)(ON)C(=O)NNC(=O)c1ccc(O)c(O)c1.Cl
HCID19917907

未命名化合物

结构：Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)C(=O)c4csc(N)n4)[C@H]3SC2)n2nc(C(=O)N(C)O)nc2n1
HCID86748864

未命名化合物

PRODUCTS

生成物

1
结构：Cc1cc(SCC2=C(C(=O)O)N3C(=O)[C@@H](NC(=O)/C(=N\OC(C)(C)C(=O)NNC(=O)c4ccc(O)c(O)c4)c4csc(N)n4)[C@H]3SC2)n2nc(C(=O)N(C)O)nc2n1
HCID88419536

未命名化合物

收率 28.3%

AUXILIARIES

试剂、催化剂与溶剂

1
结构：CC(=O)N(C)C
溶剂HCID31374

Dimethylacetamide

C4H9NO

PROCEDURE

实验过程

(6R,7R)-7-(2-Amino-4-thiazoleglyoxylamido)-3-[[[2-(N-hydroxy-N-methylcarbamoyl)-5-methyl-s-triazolo[1,5-a]pyrimidin-7-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid (40 mg) (0.066 mmol) and 29 mg (0.086 mmol) of 1-[2-(aminooxy)-2-methylpropionyl]-2-(3,4-dihydroxybenzoyl)hydrazine hydrochloride are dissolved in 1 ml of absolute dimethylacetamide. After stirring for 20 hours the solution is concentrated at room temperature in a high vacuum. The residue is crystallized from ethanol. There are obtained 16 mg of (6R,7R)-7-[(Z)-2-(2-amino-4-thiazolyl)-2-[[1-[3-(3,4-dihydroxybenzoyl)carbazoyl]-1-methylethoxy]imino]acetamido]-3-[[[2-(N-hydroxy-N-methylcarbamoyl)-5-methyl-s-triazolo[1,5-a]pyrimidin-7-yl]thio]methyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid as a brown powder.

WORKUP

后处理

  1. concentrationis concentrated at room temperature in a high vacuum
  2. customThe residue is crystallized from ethanol