反应详情

4,7-Dichloro-3-quinolinecarboxylic acid ethyl ester (72.0 g, 267 mmol) and p-aminobenzoic acid (36.6 g, 267 mmol) were refluxed in 675 ml of THF for 6 h then cooled to room temperature. The yellow precipitate was filtered, combined with the product from a 10 mmol reaction and washed with THF, then ether. The yellow powder was then dried in vacuo overnight affording 82.7 g (203 mmol, 73% yield) of 4-[(4-carboxyphenyl)amino]-7-chloro-3-quinolinecarboxylic acid ethyl ester hydrochloride.

1. filtrationThe yellow precipitate was filtered
2. customcombined with the product from a 10 mmol reaction
3. washwashed with THF
4. customThe yellow powder was then dried in vacuo overnight