反应详情

A solution 4-hydroxy-4-(3-ethylbenzo[b]thiophen-2-yl)piperidine (0.067 g, 0.273 mmol) and (S)-(+)-4-(oxiranylmethoxy)benzo[b]-furan (0.052 g, 0.273 mmol) in methanol (3 mL) was heated at reflux for 18 hours, and then cooled and evaporated. The residue was purified using silica gel chromatography (dichloromethane/2% methanol in dichloromethane gradient elution) to give the final title compound as a yellow oil (0.049 g, 41%). FDMS m/e=436 (M++1). C26H29NO3S.0.75H2O

1. temperatureat reflux for 18 hours
2. temperaturecooled
3. customevaporated
4. customThe residue was purified
5. washsilica gel chromatography (dichloromethane/2% methanol in dichloromethane gradient elution)