反应详情

To a mixture of anhydrous cupric chloride (147 g) and 2-bromo-3-chloro-4-fluoro-6-nitroaniline (235.6 g) in anhydrous acetonitrile (1.5 litter) was added tert-butylnitrite (135.2 g) at 60° C. during 70 minutes. The reaction mixture was poured into ice-chilled diluted hydrochloric acid (1.5 litter) and extracted with benzene. The organic layer was successively washed with ice-chilled diluted hydrochloric acid and water saturated with sodium chloride, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by distillation to give the title compound (218.8 g), bp 78°-117° C./2 mmHg. The oil was crystallized from methanol to give yellow prisms, mp 65.5°-67.5° C.

1. additionThe reaction mixture was poured into ice-
2. extractionextracted with benzene
3. washThe organic layer was successively washed with ice-
4. temperaturechilled diluted hydrochloric acid and water saturated with sodium chloride
5. dry with materialdried over anhydrous sodium sulfate
6. concentrationconcentrated
7. distillationThe resulting residue was purified by distillation