HRID1762950

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID7864

Chloromethyl methyl ether

C2H5ClO

HCID22565020

未命名化合物

结构：CC(CC(=O)O)N(CC(=O)c1ccc(OCc2ccccc2)c2[nH]c(C(=O)O)cc12)Cc1ccccc1.Cl

HCID70381925

未命名化合物

PRODUCTS

生成物

结构：CC(=O)O.COCOC(=O)CC(C)N(CC(=O)c1ccc(OCc2ccccc2)c2[nH]c(C(=O)OCOC)cc12)Cc1ccccc1

HCID70381294

未命名化合物

PROCEDURE

实验过程

Under the conditions of Example 21(A), 5 g of 4-[N-benzyl-N-(2-carboxy-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid hydrochloride is reacted with 1.6 g of chloromethylmethyl ether and worked up. Treatment of the crude product with dioxane/acetic acid yields 4.2 g of 4-[N-benzyl-N-(2-methoxymethoxycarbonyl-1-methylethyl)aminoacetyl]-7-benzyloxyindole-2-carboxylic acid methoxymethyl ester acetate, decomposition point 118°-122° C.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-ce23bcd3fe144526bb79bd3d3c506d84
来源数据集: uspto-grants-1989_05
DOI: 10.6084/m9.figshare.5104873.v1
专利: US04835175
来源说明: uspto-grants-1989_05

反应 SMILES

Cl.[CH2:2]([N:9]([CH2:16][C:17]([C:19]1[CH:27]=[CH:26][C:25]([O:28][CH2:29][C:30]2[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=2)=[C:24]2[C:20]=1[CH:21]=[C:22]([C:36]([OH:38])=[O:37])[NH:23]2)=[O:18])[CH:10]([CH3:15])[CH2:11][C:12]([OH:14])=[O:13])[C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.Cl[CH2:40][O:41][CH3:42].[O:43]1[CH2:48]COC[CH2:44]1.C(O)(=O)C>>[C:12]([OH:14])(=[O:13])[CH3:11].[CH3:40][O:41][CH2:42][O:37][C:36]([C:22]1[NH:23][C:24]2[C:20]([CH:21]=1)=[C:19]([C:17](=[O:18])[CH2:16][N:9]([CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1)[CH:10]([CH3:15])[CH2:11][C:12]([O:14][CH2:44][O:43][CH3:48])=[O:13])[CH:27]=[CH:26][C:25]=2[O:28][CH2:29][C:30]1[CH:35]=[CH:34][CH:33]=[CH:32][CH:31]=1)=[O:38]