反应详情

To 33 g of α-[p-(1-cyclooctenyl)-phenoxy]-heptanoic acid ethyl ester in 120 ml of ethanol are added 120 ml of 2N sodium hydroxide solutuion and the mixture is stirred for 11/2 hours at room temperature. The reaction mixture is then evaporated to dryness in vacuo and the residue partitioned between N hydrochloric acid and ether. The organic phase is washed until neutral, dried over sodium sulphate and evaporated to dryness in vacuo. The residue is crystallised from pentane to yield the 2-[p-(1-cyclooctenyl)-phenoxy]-heptanoic acid of the formula ##STR8## (m.p. 57°-60° C; b.p. 0.04 185°-188° C.

1. customThe reaction mixture is then evaporated to dryness in vacuo
2. customthe residue partitioned between N hydrochloric acid and ether
3. washThe organic phase is washed until neutral,
4. dry with materialdried over sodium sulphate
5. customevaporated to dryness in vacuo
6. customThe residue is crystallised from pentane