反应详情

The title compound was prepared from a mixture of 4-chloro-2-phenyl-6-(trifluoromethyl)pyrimidine (50 mg, 0.193 mmol) and 3,4-dimethoxyaniline (44 mg, 0.290 mmol) similar to Example 75. The mixture was extracted with ethyl acetate (75 ml), washed with water (2×25 ml), washed with aqueous saturated NaCl (1×25 ml), and dried over anhydrous sodium sulfate. The ethyl acetate solution was rotary evaporated to dryness. The residual was purified by column chromatography and isolated as a yellow oil (35 mg, 48%). 1H NMR (CDCl3): 8.45–8.42 (m, 2H), 7.50–7.44 (m, 3H), 7.25 (s, 1H), 7.02 (s, 1H), 6.90 (s, 2H), 6.74 (s, 1H), 3.91 (s, 3H), 3.87 (s, 3H).

1. extractionThe mixture was extracted with ethyl acetate (75 ml)
2. washwashed with water (2×25 ml)
3. washwashed with aqueous saturated NaCl (1×25 ml)
4. dry with materialdried over anhydrous sodium sulfate
5. customThe ethyl acetate solution was rotary evaporated to dryness
6. customThe residual was purified by column chromatography