反应详情

温度

-5 °C

Azetidin-3-ol hydrochloride (2 g, 18,3 mmoles) was dissolved in a 5% weight/weight (45 ml) of an aqueous solution of sodium hydroxide, the resulting solution cooled to −5° C. and under vigorous stirring 3,5-di-tert-butyl-4-hydroxy-benzoyl chloride (5,4 g, 20 mmoles) obtained according to step (a) dissolved in 8 ml of THF was added. Afterwards the cooling bath was removed, the reaction mixture warmed to room temperature (approximately 25° C.) and stirred for an additional hour under these conditions. The reaction mixture was then extracted several times with diethyl ether, the etherical phases combined, washed with water, dried with sodium sulfate and evaporated to dryness to obtain 1,9 g of the crude product, which is crystallized from ethyl acetate-petroleum ether. 1,6 g (30% of theoretical yield) of (3,5-di-tert-butyl-4-hydroxy-phenyl)-(3-hydroxy-azetidin-1-yl)-methanone were obtained in crystalline form.

1. customobtained
2. additionwas added
3. customAfterwards the cooling bath was removed
4. temperaturethe reaction mixture warmed to room temperature (approximately 25° C.)
5. extractionThe reaction mixture was then extracted several times with diethyl ether
6. washwashed with water
7. dry with materialdried with sodium sulfate
8. customevaporated to dryness
9. customto obtain 1,9 g of the crude product, which
10. customis crystallized from ethyl acetate-petroleum ether