反应详情

tert-Butyl 3-(2-methoxyethenyl)-1-piperidinecarboxylate (1.16 g, 4.81 mmol) was dissolved in 90% formic acid (2 mL). The mixture was stiffed at room temperature for 40 min. The mixture was then partitioned between ethyl acetate and saturated aqueous NaHCO3 solution. The separated organic phase was washed with brine, dried over Na2SO4, filtered and evaporated. Purification by column chromatography (hexane/ethyl acetate=4/1) gave tert-butyl 3-(2-oxoethyl)-1-piperidinecarboxylate as a colorless oil (652 mg, yield; 60%). [Starting Compound 2H]

1. customThe mixture was then partitioned between ethyl acetate and saturated aqueous NaHCO3 solution
2. washThe separated organic phase was washed with brine
3. dry with materialdried over Na2SO4
4. filtrationfiltered
5. customevaporated
6. customPurification by column chromatography (hexane/ethyl acetate=4/1)