反应详情

To a solution of [rac]-(6-{1-[4-methyl-2-(4-trifluoromethyl-phenyl)-thiazol-5-yl]-ethoxy}-indol-1-yl)-acetic acid tert-butyl ester (30 mg, 58 μmol) in THF/methanol 2/1 (4.5 ml) was added a 1 N aqueous NaOH solution (1.5 ml). The reaction mixture was stirred for 14 h at ambient temperature, neutralized with 1 N aqueous HCl solution under ice cooling and concentrated under reduced pressure. The residue was dissolved in 1 N HCl/ice water 1/1 and ethyl acetate, the layers were separated and the aqueous layer was extracted with ethyl acetate. The combined organic layers were washed with ice water/brine 1/1, dried over sodium sulfate and the solvent was evaporated in vacuo to give the title compound (24 mg, 52 μmol, 90%) as light yellow oil.

1. concentrationconcentrated under reduced pressure
2. dissolutionThe residue was dissolved in 1 N HCl/ice water 1/1
3. customethyl acetate, the layers were separated
4. extractionthe aqueous layer was extracted with ethyl acetate
5. washThe combined organic layers were washed with ice water/brine 1/1
6. dry with materialdried over sodium sulfate
7. customthe solvent was evaporated in vacuo