反应详情

A mixture of 0.4 g (1.23 mmole) of (3R, 5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-methyldihydrofuran-2(3H)-one (prepared as described in Preparation 2) and 6 ml of butylamine was heated under reflux for 3.0 hours, whilst stirring. At the end of this time, the reaction mixture was concentrated by distillation under reduced pressure, after which the residue was purified by column chromatography through silica gel (using ethyl acetate as the eluent) to afford 0.48 g of the title compound as a white powder.

1. temperaturewas heated
2. temperatureunder reflux for 3.0 hours
3. concentrationAt the end of this time, the reaction mixture was concentrated by distillation under reduced pressure
4. customafter which the residue was purified by column chromatography through silica gel (