反应详情

A solution of 293 mg (0.9 mmole) of (3R, 5S)-5-[(1S)-1-(t-butoxycarbonyl)amino-2-cyclohexylethyl]-3-methyldihydrofuran-2(3H)-one (prepared as described in Preparation 2) in 3 ml of methanol was mixed with 3 ml of propylamine, whilst ice-cooling, and the mixture was allowed to stand overnight at room temperature. At the end of this time, the reaction mixture was concentrated by distillation under reduced pressure, and the residue was triturated with hexane to afford 315 mg of the title compound as white crystals, melting at 115°-116° C.

1. temperaturecooling
2. concentrationAt the end of this time, the reaction mixture was concentrated by distillation under reduced pressure
3. customthe residue was triturated with hexane