反应详情

A solution of tert-butyl (3-(3-chloroquinoxaline-6-carbonyl)-2,4-difluorophenyl) carbonate (42 mg, 0.1 mmol, 1.0 eq.) in TFA/DCM (1.5 mL/1.5 mL) was stirred at rt for 2 h, then concentrated. The residue was purified via flash column chromatography (PE/EA=4/1, v/v) to afford (3-chloroquinoxalin-6-yl)(2,6-difluoro-3-hydroxyphenyl)methanone as a yellow solid (19.9 mg) LRMS (M−H+) m/z calculated 319.0, found 318.9. 1H NMR (CDCl3, 400 MHz) δ 8.81 (s, 1 H), 8.31-8.34 (m, 2 H), 8.18-8.20 (d, 1 H), 7.08-7.14 (m, 1 H), 6.86-6.88 (m, 1 H), 5.43 (s, 1 H).

1. concentrationconcentrated
2. customThe residue was purified via flash column chromatography (PE/EA=4/1