HRID1775042

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID14537079

Methyl 4-[(tert-butoxycarbonyl)amino]piperidine-4-carboxylate

C12H22N2O4

结构：Fc1cccc(-c2nn(C3CCCCO3)c3cnc(-c4cccnc4)cc23)n1

HCID71253662

未命名化合物

PRODUCTS

生成物

结构：COC(=O)C1(NC(=O)OC(C)(C)C)CCN(c2cccc(-c3nn(C4CCCCO4)c4cnc(-c5cccnc5)cc34)n2)CC1

HCID71253540

未命名化合物

收率 67%

PROCEDURE

实验过程

Following the procedures of Example 144, and starting with 3-(6-Fluoropyridin-2-yl)-5-(pyridin-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridine and methyl 4-(tert-butoxycarbonylamino)piperidine-4-carboxylate were reacted and purified via silica gel chromatography using a gradient of EtOAc in heptane to afford 241 mg (67%) of Methyl 4-(tert-butoxycarbonylamino)-1-(6-(5-(pyridin-3-yl)-1-(tetrahydro-2H-pyran-2-yl)-1H-pyrazolo[3,4-c]pyridin-3-yl)pyridin-2-yl)piperidine-4-carboxylate. ESI MS m/z 614.2 (M+1).

WORKUP

后处理

customwere reacted
custompurified via silica gel chromatography

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-468fce702f254d7790f64a8da366d6fe
来源数据集: uspto-grants-2016_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US09260425B2
来源说明: uspto-grants-2016_02

反应 SMILES

F[C:2]1[N:7]=[C:6]([C:8]2[C:16]3[C:11](=[CH:12][N:13]=[C:14]([C:17]4[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=4)[CH:15]=3)[N:10]([CH:23]3[CH2:28][CH2:27][CH2:26][CH2:25][O:24]3)[N:9]=2)[CH:5]=[CH:4][CH:3]=1.[C:29]([O:33][C:34]([NH:36][C:37]1([C:43]([O:45][CH3:46])=[O:44])[CH2:42][CH2:41][NH:40][CH2:39][CH2:38]1)=[O:35])([CH3:32])([CH3:31])[CH3:30]>>[C:29]([O:33][C:34]([NH:36][C:37]1([C:43]([O:45][CH3:46])=[O:44])[CH2:42][CH2:41][N:40]([C:2]2[CH:3]=[CH:4][CH:5]=[C:6]([C:8]3[C:16]4[C:11](=[CH:12][N:13]=[C:14]([C:17]5[CH:18]=[N:19][CH:20]=[CH:21][CH:22]=5)[CH:15]=4)[N:10]([CH:23]4[CH2:28][CH2:27][CH2:26][CH2:25][O:24]4)[N:9]=3)[N:7]=2)[CH2:39][CH2:38]1)=[O:35])([CH3:32])([CH3:31])[CH3:30]