反应详情

tert-Butyl (3R)-3-[(4-methyl-2-pyridyl)amino]piperidine-1-carboxylate (271 mg, 0.93 mmol) was dissolved in methanol (1 ml). Hydrochloric acid (4N in dioxane, 4.65 ml, 18.6 mmol) was added and the mixture was stirred at room temperature for three hours. The mixture was concentrated under reduced pressure, the residue was treated twice with diethylether and separated by decantation, dissolved in methanol and evaporated to dryness to yield 246 mg (quantitative) MS (ESI) m/z=192.2 [M+1]+.

1. concentrationThe mixture was concentrated under reduced pressure
2. additionthe residue was treated twice with diethylether
3. customseparated by decantation
4. dissolutiondissolved in methanol
5. customevaporated to dryness
6. customto yield 246 mg (quantitative)