反应详情

To a solution of 4-(4,6-dichloropyrimidin-2-yl)morpholine (468 mg, 2.0 mmol) in THF (20 mL) was added n-butyllithium (1.56 mL, 1.6 M) dropwise at −78° C. After stirring for 30 min, 1,3,2-dioxathiolane 2,2-dioxide (336 mg, 2.71 mmol) was added, and after stirring for an additional 40 min, 6 N HCl (6.67 mL) was added. The reaction was stirred at room temperature for 18 h and then at 40° C. for 4 h. The reaction mixture was extracted with ethyl acetate and the organic layer was washed with brine, dried with MgSO4, filtered and concentrated by rotary evaporation. The resulting residue was purified by silica gel chromatography using a gradient of EtOAc/heptane (25-75%) to give the title compound (231 mg, 42%). 1H NMR (400 MHz, CDCl3) δ 3.84 (t, J=7.0 Hz, 2 H), 3.80-3.76 (m, 4 H), 3.76-3.72 (m, 4 H), 3.04 (t, J=7.0 Hz, 2 H). m/z (APCI+) for C10H13Cl2N3O2 277.9 (M+H)+.

1. stirringafter stirring for an additional 40 min
2. stirringThe reaction was stirred at room temperature for 18 h
3. waitat 40° C. for 4 h
4. extractionThe reaction mixture was extracted with ethyl acetate
5. washthe organic layer was washed with brine
6. dry with materialdried with MgSO4
7. filtrationfiltered
8. concentrationconcentrated by rotary evaporation
9. customThe resulting residue was purified by silica gel chromatography