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HRID1777833

反应详情

EQUATION

反应方程式

HRID 1777833 的结构方程式

REACTANTS

反应物

2
结构：CC(C)[C@H]1c2ncc(C(=O)O)cc2C(C)N1C(=O)OC(C)(C)C
HCID118274884

未命名化合物

结构：CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3c(c2)CN(C(=O)OC(C)(C)C)[C@H]3C(C)C)cc1
HCID118274902

未命名化合物

PRODUCTS

生成物

1
结构：CCS(=O)(=O)c1ccc(CNC(=O)c2cnc3c(c2)C(C)N(C(=O)OC(C)(C)C)[C@H]3C(C)C)cc1
HCID118274940

未命名化合物

PROCEDURE

实验过程

Procedure same as that for tert-butyl(S)-3-((4-(ethylsulfonyl)benzyl)carbamoyl)-7-isopropyl-5,7-dihydro-6H-pyrrolo[3,4-b]pyridine-6-carboxylate, using (7S)-6-(tert-butoxycarbonyl)-7-isopropyl-5-methyl-6,7-dihydro-5H-pyrrolo[3,4-b]pyridine-3-carboxylic acid as a starting material. LC-MS tR=0.95 min in 1 min chromatography, MS (ESI) m/z 502.6 [M+H]+. 1H NMR (CD3OD, 400 MHz, mixture of diastereomers): δ 8.93 (s, 1H), 7.79 (d, J=8.4 Hz, 2H), 7.50 (d, J=8.4 Hz, 2H), 7.24 (s, 1H), 5.06-4.88 (m, 2H), 4.82-4.70 (m, 2H), 3.06 (q, J=7.2 Hz, 2H), 2.48-2.26 (m, 1H), 1.59 (d, J=7.2 Hz, 0.9H), 1.56 (d, J=7.2 Hz, 2.1H), 1.53 (s, 9H), 1.25 (t, J=7.2 Hz, 3H), 1.09 (d, J=7.2 Hz, 0.9H), 0.97 (broad s, 2.1H), 0.83 (broad s, 2.1H), 0.48 (d, J=7.2 Hz, 0.9H).