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HRID1780241

反应详情

EQUATION

反应方程式

HRID 1780241 的结构方程式

REACTANTS

反应物

2
结构：NC(=O)C[C@H](NC(=O)OCc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)[C@H](O)C(=O)O
HCID57125825

未命名化合物

结构：CC(C)(C)NC(=O)[C@@H]1[C@@H](O)CCN1C(=O)OC(C)(C)C
HCID70050913

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)NC(=O)[C@@H]1[C@@H](O)CCN1C(=O)[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)OCc1ccccc1
HCID473133

未命名化合物

收率 65.4%

PROCEDURE

实验过程

Following a procedure similar to that described in Example 11, 28 mg (0.10 mmol) of (3S)-1-t-butoxycarbonyl-N-t-butyl-3-hydroxy-L-prolinamide (prepared as described in Preparation 13) was deprotected to remove the t-butoxycarbonyl group. The resulting (3S)-N-t-butyl-3-hydroxy-L-prolinamide was then condensed with 52 mg (0.12 mmol) of (2S,3S)-3-(N2 -benzyloxycarbonyl-L-asparaginyl)amino-2-hydroxy-4-phenylbutyric acid (prepared as described in Preparation 1), to give 40 mg of the title compound as a white powder, melting at 111°-113° C.

WORKUP

后处理

  1. customto remove the t-butoxycarbonyl group