Potassium tert-butoxide → 1-Cyclopentyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]pyrimido-[4,5-d]pyrimidin-2(1H)-one

HRID 1783517Notes

Reaction equation

HRID 1783517 reaction equation
[CH:1]1([N:6]2[C:11]3=[N:12][C:13]([NH:16][C:17]4[CH:22]=[CH:21][C:20]([N:23]5[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]5)=[CH:19][CH:18]=4)=[N:14][CH:15]=[C:10]3[CH2:9][NH:8][C:7]2=[O:30])[CH2:5][CH2:4][CH2:3][CH2:2]1.CC(C)([O-])C.[K+]>C1COCC1>[CH:1]1([N:6]2[C:11]3=[N:12][C:13]([NH:16][C:17]4[CH:18]=[CH:19][C:20]([N:23]5[CH2:28][CH2:27][N:26]([CH3:29])[CH2:25][CH2:24]5)=[CH:21][CH:22]=4)=[N:14][CH:15]=[C:10]3[CH:9]=[N:8][C:7]2=[O:30])[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 23665647Potassium tert-butoxideHCID 571665711-Cyclopentyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one

Product 1

HCID 688592401-Cyclopentyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]pyrimido-[4,5-d]pyrimidin-2(1H)-oneYield 67%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Prepared from 150 mg (0.37 mmol) of 1-cyclopentyl-7-[4-(4-methylpiperazin-1-yl)phenylamino]-3,4-dihydro-pyrimido[4,5-d]pyrimidin-2(1H)-one and 165 mg (1.47 mmol) of potassium tert-butoxide in 6 mL of THF. The dark orange semi-solid is triturated in diethyl ether, and the yellow powder is collected and dried to give 100 mg (67%) of the title compound: mp 220-225° C. (dec).

Workup

  1. customThe dark orange semi-solid is triturated in diethyl ether
  2. customthe yellow powder is collected
  3. customdried

Sources & evidence

ORD record
ord-ed0b76cefeb7424982a53a017679755b
Source dataset
uspto-grants-2009_03
Patent number
US07501425B1

Reaction notes

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