反应详情

To the methyl triphenylphosphoniumbromide (4.3 grn, 12 mmol) in THF at 0° C., n-BuLi (1.6M, 7.5 ml, 12 mmol) was added and stirred for 30 min. Then 3-acetylbenzonitrile in THF was slowly added and the reaction mixture was stirred at 0° C. for further 3 h. Then reaction mixture was quenched with aqeous ammonium chloride and diluted with ethyl acetate. Organic layer was washed with water, brine and dried. Crude residue after column purification yielded 3-(prop-1-en-2-yl)benzonitrile in 86% yield.

1. stirringthe reaction mixture was stirred at 0° C. for further 3 h
2. customThen reaction mixture
3. customwas quenched with aqeous ammonium chloride
4. additiondiluted with ethyl acetate
5. washOrganic layer was washed with water, brine
6. customdried
7. customCrude residue after column purification