Sodium bis(trimethylsilyl)amide → 1-{3-[(4-{[5-Chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]amino}-6-methoxyquinazolin-7-yl)oxy]propyl}-4-methylpiperazin-2-one

HRID 1785139Notes

Reaction equation

HRID 1785139 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][C:19]3=[O:25])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:26][C:27]1[CH:35]=[C:34]([C:36]#[C:37][CH2:38][O:39][CH3:40])[C:30]2[O:31][CH2:32][O:33][C:29]=2[C:28]=1[NH2:41].C[Si]([N-][Si](C)(C)C)(C)C.[Na+]>CN(C=O)C>[Cl:26][C:27]1[CH:35]=[C:34]([C:36]#[C:37][CH2:38][O:39][CH3:40])[C:30]2[O:31][CH2:32][O:33][C:29]=2[C:28]=1[NH:41][C:2]1[C:11]2[C:6](=[CH:7][C:8]([O:14][CH2:15][CH2:16][CH2:17][N:18]3[CH2:23][CH2:22][N:21]([CH3:24])[CH2:20][C:19]3=[O:25])=[C:9]([O:12][CH3:13])[CH:10]=2)[N:5]=[CH:4][N:3]=1

Participants

5

Reactant 3

HCID 2724254Sodium bis(trimethylsilyl)amideHCID 210827165-Chloro-7-(3-methoxyprop-1-ynyl)-1,3-benzodioxol-4-amineHCID 866015631-{3-[(4-Chloro-6-methoxyquinazolin-7-yl)oxy]propyl}-4-methylpiperazin-2-one

Product 1

HCID 688817431-{3-[(4-{[5-Chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-yl]amino}-6-methoxyquinazolin-7-yl)oxy]propyl}-4-methylpiperazin-2-oneYield 76%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

This was prepared by the method described in example 4 using 1-{3-[(4-chloro-6-methoxyquinazolin-7-yl)oxy]propyl}-4-methylpiperazin-2-one (200 mg, 0.55 mmol), 5-chloro-7-(3-methoxyprop-1-yn-1-yl)-1,3-benzodioxol-4-amine (145 mg, 0.60 mmol) and sodium bis(trimethylsilyl)amide (1.0M in THF, 1.15 ml) in DMF (3 ml). The crude product was purified by column chromatography on silica using ethyl acetate as eluent. There was thus obtained the title compound (237 mg, 76%) as a pale yellow solid; NMR Spectrum:(DMSOd6) 2.05 (quintet, 2H), 2.20 (s, 3H), 2.58 (t, 2H), 2.92 (s, 2H), 3.33 (t, 2H), 3.36 (s, 3H), 3.48 (t, 2H), 3.94 (s, 3H), 4.13 (t, 2H), 4.37 (s, 2H), 6.15 (s, 2H), 7.15 (s, 2H), 7.82 (s, 1H), 8.34 (s, 1H), 9.51 (s, 1H); Mass Spectrum: M+H+ 568/570.

Workup

  1. customThis was prepared by the method
  2. customThe crude product was purified by column chromatography on silica

Sources & evidence

ORD record
ord-5cf72278c1fa4850a46bafb6034c8bcc
Source dataset
uspto-grants-2009_03
Patent number
US07504408B2

Reaction notes

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