反应详情

This material was prepared from 1-benzhydryl-3-[2-(trifluoromethyl)-4′-(methylsulfonyl)benzhydryloxy]azetidine (170) (6.9 mmol) using the procedure described for compound (4). After basic aqueous workup, purification by flash column chromatography [SiO2; ethyl acetate-methanol (90:10)→ethyl acetate-methanol—ammonium hydroxide (90:10:5)] afforded the desired product as a pale yellow oil (234 mg, 9% over 2 steps).

1. customAfter basic aqueous workup, purification by flash column chromatography [SiO2; ethyl acetate-methanol (90:10)→ethyl acetate-methanol—ammonium hydroxide (90:10:5)]