反应详情

(2S,4R)-4-(4-{4-[Acetyl-(4-chloro-phenyl)-amino]-2-methyl-3,4-dihydro-2H-quinoline-1-carbonyl}-phenoxy)-2-methyl-butyric acid methyl ester (100 mg) was dissolved in methanol/THF, and lithium hydroxide (1.0N, 2 mL) was added. After 1 hour, the reaction was acidified and extracted with methylene chloride. The organic layer was dried, filtered, and concentrated. The crude residue was purified by silica gel chromatography ethyl acetate—5% MeOH/ethyl acetate gradient) to afford the product.

1. extractionextracted with methylene chloride
2. customThe organic layer was dried
3. filtrationfiltered
4. concentrationconcentrated
5. customThe crude residue was purified by silica gel chromatography ethyl acetate—5% MeOH/ethyl acetate gradient)
6. customto afford the product