反应详情

温度

60 °C

tert-Butyl {2-[4-({3-methyl-4-[3-(trifluoromethyl)phenoxy]phenyl}amino)-5H-pyrrolo[3,2-d]pyrimidin-5-yl]ethyl}carbamate (2.9 g) obtained in Example 188 (i) was dissolved in tetrahydrofuran (80 mL)/2N hydrochloric acid (40 mL), and the mixture was stirred at 60° C. for 16 hrs. The reaction mixture was concentrated under reduced pressure, ethanol (80 mL) was added to the residue and the mixture was concentrated again under reduced pressure. Ethyl acetate was added to the residue and the solid was collected by filtration and dried under reduced pressure to give the title compound (2.58 g) as a solid powder.

1. concentrationThe reaction mixture was concentrated under reduced pressure, ethanol (80 mL)
2. additionwas added to the residue
3. concentrationthe mixture was concentrated again under reduced pressure
4. additionEthyl acetate was added to the residue
5. filtrationthe solid was collected by filtration
6. customdried under reduced pressure