反应详情

温度

-30 °C

The 3-tert-butoxycarbonylaminopyridine (2.0035 g, 10.32 mmol) was dissolved in THF (100 mL). The solution was cooled to −30° C. in a dry ice/acetonitrile bath, then t-BuLi (13 mL, 22.1 mmol) was added dropwise. After 1 h, 4-chlorophenyl isocyanate (1.911 g, 12.44 mmol) was added. The reaction mixture was warmed to 0° C. After 1.5 h, the reaction was warmed to room temperature. After 3 h at room temperature, the reaction was quenched with water (100 mL) and extracted with EtOAc (800 mL). The organic layer was washed with water (2×50 mL), dried over sodium sulfate, filtered, and concentrated. The crude material was purified by flash column chromatography (350 g silica, 30% EtOAc/-CH2Cl2) to give the amide (1.284 g, 3.69 mmol, 36%) as a pale yellow solid.

1. temperatureThe reaction mixture was warmed to 0° C
2. waitAfter 1.5 h
3. temperaturethe reaction was warmed to room temperature
4. waitAfter 3 h at room temperature
5. customthe reaction was quenched with water (100 mL)
6. extractionextracted with EtOAc (800 mL)
7. washThe organic layer was washed with water (2×50 mL)
8. dry with materialdried over sodium sulfate
9. filtrationfiltered
10. concentrationconcentrated
11. customThe crude material was purified by flash column chromatography (350 g silica, 30% EtOAc/-CH2Cl2)