反应详情

A solution of 1,4-dihydro-2-methoxy-6-methyl-4-(3-nitrophenyl)-5-pyrimidinecarboxylic acid, 1-methyethyl ester (2.0 g, 6.0 mmol) in dimethylformamide (7.0 ml) was treated with finely ground potassium carbonate (1.7 g, 12.0 mmoles), N-benzyl-3-chloro-N-methylpropylamine (2.37 g, 12.0 mmol) and a catalytic amount of 18-crown-6. The reaction was heated at 70°-75° C. under argon overnight. The reaction was allowed to cool down to room temperature and was diluted with ether. It was filtered, and the filtrate was washed with water, brine and was dried over anhydrous magnesium sulfate. Evaporation of solvent provided a brown oil which was purified by flash chromatography (20% acetone in hexanes) to yield the title compound (1.51 g) as a yellow oil.

1. temperatureThe reaction was heated at 70°-75° C. under argon overnight
2. filtrationIt was filtered
3. washthe filtrate was washed with water, brine
4. dry with materialwas dried over anhydrous magnesium sulfate
5. customEvaporation of solvent
6. customprovided a brown oil which
7. customwas purified by flash chromatography (20% acetone in hexanes)