反应详情

2-Fluoro-6-(trifluoromethyl)benzaldehyde (1.51 g, 7.8 mmoles), methyl 4-fluoro-3-oxobutanoate (1.06 g, 7.8 mmoles) and 1-methylethyl 3-amino-2-butenoate (1.13 g, 7.8 mmoles) were heated at 90° under nitrogen with stirring for 2 hours. The cooled reaction mixture was chromatographed twice; first eluting with toluene/ethyl acetate mixtures and then with ethyl acetate/petroleum ether (60°-80°) mixtures. The title compound (0.1 g) was obtained on evaporation of the pure fractions mp 82°-4°.

1. customThe cooled reaction mixture
2. customwas chromatographed twice
3. washfirst eluting with toluene/ethyl acetate mixtures
4. customwith ethyl acetate/petroleum ether (60°-80°)