反应详情

480 mg of (+)-N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carbothioamide and 339 mg of methyl trans-3-(4-methoxyphenyl)glycidate are dissolved in 40 ml of ethanol, and the solution is refluxed for 11 hours under heating. 339 mg of methyl trans-3-(4-methoxyphenyl)glycidate are added to the mixture, and the mixture is further refluxed for 3 hours. The mixture is concentrated under reduced pressure to remove solvent. The residue is purified by silica gel chromatography (solvent, chloroform:ethanol=40:1), and the resultant product is recrystallized from a mixture of ethyl acetate and n-hexane. 350 mg of (+)-N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine-3-carboxamide are obtained. Yield: 75.7%.

1. temperaturethe solution is refluxed for 11 hours
2. temperatureunder heating
3. temperaturethe mixture is further refluxed for 3 hours
4. concentrationThe mixture is concentrated under reduced pressure
5. customto remove solvent
6. customThe residue is purified by silica gel chromatography (solvent, chloroform:ethanol=40:1)
7. customthe resultant product is recrystallized from a mixture of ethyl acetate and n-hexane