反应详情

3.69 g of 2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidine are dissolved in 40 ml of tetrahydrofuran, and 0.62 g of methyl isocyanate is added thereto at room temperature. The mixture is stirred at the same temperature for 2 hours. The mixture is concentrated under reduced pressure to remove solvent. Water is added to the residue, and crystalline precipitates are collected by filtration. The crystals are washed with ethanol and ether, and then recrystallized from a mixture of ethyl acetate and n-hexane. 3.82 g of N-methyl-2-{2-[2-(4-phenylpiperazin-1-yl)ethyloxy]phenyl}thiazolidin-3-carboxamide are obtained. Yield: 89.7%.

1. customat room temperature
2. concentrationThe mixture is concentrated under reduced pressure
3. customto remove solvent
4. additionWater is added to the residue
5. customcrystalline precipitates
6. filtrationare collected by filtration
7. washThe crystals are washed with ethanol and ether
8. customrecrystallized from a mixture of ethyl acetate and n-hexane