反应详情

t-Butoxycarbonylamino-3-[2-(4-cyanophenyl)ethoxy]-2-methylbenzene (2.69 g, 7.64 mmol; from step (ii) above) were dissolved in EtOAc, pre-saturated with HCl(g), (150 mL) under nitrogen and stirred at room temperature overnight. After evaporation of the solvent the residue was partitioned between 10% aqueous HCl and EtOAc. The aqueous phase was washed with EtOAc, basified with NaOH (2M, aq.) and extracted with EtOAc. The combined organic phases were washed with brine, dried (MgSO4) and the solvent evaporated to afford 0.42 g (19%) of the sub-title compound.

1. customAfter evaporation of the solvent the residue
2. customwas partitioned between 10% aqueous HCl and EtOAc
3. washThe aqueous phase was washed with EtOAc
4. extractionextracted with EtOAc
5. washThe combined organic phases were washed with brine
6. dry with materialdried (MgSO4)
7. customthe solvent evaporated