反应详情

N-{3-[2-(4-Cyanophenyl)ethoxy]phenyl}benzenesulfonamide (0.179 g; 0.47 mmol; from Example 1(iv) above), K2CO3 (0.082 g; 0.59 mmol) and ethyl bromoacetate (63 μL; 0.57 mmol) were stirred in DMF (10 mL) for 1 hour at room temperature, then 1 hour at 60° C. The mixture was filtered and the solvent removed in vacuo. The residue was dissolved in EtOAc and washed with water. The aqueous phase was extracted with EtOAc. The combined organic portions were dried (Na2SO4) and the solvent evaporated to afford the sub-title compound in a quantitative yield.

1. custom1 hour
2. customat 60° C
3. filtrationThe mixture was filtered
4. customthe solvent removed in vacuo
5. dissolutionThe residue was dissolved in EtOAc
6. washwashed with water
7. extractionThe aqueous phase was extracted with EtOAc
8. dry with materialThe combined organic portions were dried (Na2SO4)
9. customthe solvent evaporated