反应详情

4-[7-(2-Methoxyphenyl)-1-(ethoxycarbonylmethyl)-3-methyl-2,6-dioxo-2,3,6,7-tetrahydro-1H-purin-8-yl]piperazine-1-carboxylic acid tert-butyl ester (9 mg) was dissolved in ethanol (1 ml), and 5 N sodium hydroxide aqueous solution (0.1 ml) was added thereto. The reaction mixture was left standing at room temperature for 5 hours, and neutralized with 1 N hydrochloric acid. The reaction mixture was extracted with ethyl acetate, the organic layer was dried over anhydrous magnesium sulfate, and was filtered. The filtrate was concentrated under reduced pressure to give 3 mg of the title compound.

1. waitThe reaction mixture was left
2. extractionThe reaction mixture was extracted with ethyl acetate
3. dry with materialthe organic layer was dried over anhydrous magnesium sulfate
4. filtrationwas filtered
5. concentrationThe filtrate was concentrated under reduced pressure