反应详情

To 1α,3β-bis(tert-butyldimethylsilyloxy)-17β-{4-ethyl-4-(triethylsilyloxy)hexyloxymethyl}androsta-5,7-diene (180 mg), was added a 1M tetra-n-butylammonium fluoride tetrahydrofuran solution (6 ml), followed by reflux under heating for 5 hours. After adding ethyl acetate, the mixture was washed with saturated brine, a saturated aqueous sodium bicarbonate solution and then saturated brine. The organic layer was dried over anhydrous magnesium sulfate, evaporated under reduced pressure to remove the solvent and the resulting residue was purified by column chromatography (ethyl acetate) to give the titled compound (0.10 g).

1. temperatureby reflux
2. temperatureunder heating for 5 hours
3. washthe mixture was washed with saturated brine
4. dry with materialThe organic layer was dried over anhydrous magnesium sulfate
5. customevaporated under reduced pressure
6. customto remove the solvent
7. customthe resulting residue was purified by column chromatography (ethyl acetate)