反应详情

100 mL of tetrahydrofuran was placed into a four-neck round-bottom flask, then 7.92 g (0.05 mol) of 4-fluorobenzoyl chloride and 0.53 g (1.5 mmol) of tris(acetylacetone)iron (III) were added and stirred under a nitrogen atmosphere. To this solution pentylmagnesium bromide was added at a room temperature and stirred at a room temperature for 10 min. After completion of the reaction, this solution was acidified with dilute hydrochloric acid and the organic phase was extracted with diethyl ether. Further, the organic phase was neutralized with satd. sodium hydrogencarbonate solution and washed with satd. sodium chloride solution. The organic phase was dehydrated with anhydrous magnesium sulfate, then diethyl ether was evaporated by a rotary evaporator and dried by a vacuum pump to obtain crude FPHxO.

1. stirringstirred at a room temperature for 10 min
2. customAfter completion of the reaction
3. extractionthe organic phase was extracted with diethyl ether
4. washsodium hydrogencarbonate solution and washed with satd
5. customdiethyl ether was evaporated by a rotary evaporator
6. customdried by a vacuum pump
7. customto obtain crude FPHxO