反应详情

To a stirred solution of [1-(4-Chloro-benzyl)-1H-indol-3-yl]-[4-pyridin-2-yl-1-(2-trimethylsilanyl-ethoxymethyl)-1H-imidazol-2-yl]-methanone (10 mg, 18.4 mmol) in ethanol (3 mL) was added 5 drops of concentrated HCl. The resultant solution was heated to 70° C. for 10 hours. Volatile components were then removed under reduced pressure. Pure product [1-(4-Chloro-benzyl)-1H-indol-3-yl]-(4-pyridin-2-yl-1H-imidazol-2-yl)-methanonone was precipitated out from diethyl ether (7 mg, 92%). 1H NMR (CD3OD/THF-d8): 5.7 (s, 2H), 7.2–7.5 (m, 7H), 7.9 (s, 1H), 8.45–8.65 (m, 2H), 8.85 (br, 1H), 9.85 (br, 1H). ESMS calcd for (C24H17ClN4O): 412.1; found: 413.1 (M+H)+.

1. customVolatile components were then removed under reduced pressure
2. customPure product [1-(4-Chloro-benzyl)-1H-indol-3-yl]-(4-pyridin-2-yl-1H-imidazol-2-yl)-methanonone was precipitated out from diethyl ether (7 mg, 92%)