反应详情

3-Methyl-4-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-benzoic acid methyl ester of Example 28, Step A (0.500 g, 1.81 mmol) and 3,3,5,5-tetramethyl-cyclohex-1-en-1-yl trifluoromethanesulfonate (0.621 g, 2.17 mmol) were reacted by the procedure described in Example 1, Step F. Purification by flash column chromatography on silica gel, eluting with a solvent gradient of from 0 to 5% ethyl acetate in hexane, afforded the title compound (0.390 g) as a light yellow oil.

1. customPurification by flash column chromatography on silica gel
2. washeluting with a solvent gradient of from 0 to 5% ethyl acetate in hexane