反应详情

The title compound was prepared from 3,4-dimethoxy-N-[4-(4-oxo-piperidin-1-yl)-phenyl]-benzenesulfonamide (which was obtained in Example 242) and 5-(3-amino-(2S)-2-hydroxy-propoxy)-8-hydroxy-3,4-dihydro-1H-quinolin-2-one (which was obtained in Example 12) according to the procedure of Example 278 as a white solid; 1H NMR (300 MHz, DMSO-d6) δ 1.20–1.40 (m, 2 H), 1.80–1.95 (m, 2 H), 2.39 (t, J=7.2 Hz, 2 H), 2.50–2.75 (m, 5 H), 2.82 (t, J=7.2 Hz, 2 H), 3.45–3.55 (m, 2 H), 3.63 (s, 3 H), 3.72(s, 3 H), 3.70–3.85 (m, 3 H), 4.91 (brs, 1 H), 6.44 (d, J=8.8 Hz, 1 H), 6.60 (d, J=8.8 Hz, 1 H), 6.78 (d, J=9.1 Hz, 1 H), 6.88 (d, J=9.1 Hz, 1 H), 7.02 (d, J=8.5 Hz, 1 H), 7.18 (dd, J=8.5, 2.1 Hz, 1 H), 7.36 (d, J=2.1 Hz, 1 H), 8.72 (s, 1 H), 9.17 (brs, 1 H); MS (ES) m/z: 627.1 (MH+); HRMS Calcd. for C31H39N4O8S (MH+): 627.2489. Found: 627.2458.