反应详情

To a solution of [2-(4-fluorophenyl)-1,3-oxazolin-4-yl]methan-1-ol (500 mg, 2.5 mmol) in pyridine (30 ml) cooled to 0° under inert conditions was added triphenylphosphine (1.3 g, 5.0 mmol). Carbon tetrabromide (817 mg, 2.5 mmol) was added in 4 fractions (˜200 mg each). The reaction mixture was stirred at zero degrees until all starting material was consumed, as shown by TLC (1:1 EtOAc:Hexanes). Methanol (˜5 ml) was added to quench the reaction. The solution was evaporated under reduced pressure, and the residue was purified using column chromatography (1:1 EtOAc:Hexanes) to yield compound 4-(bromomethyl)-2-(4-fluorophenyl)-1,3-oxazoline (300 mg, HNMR).

1. customwas consumed
2. additionMethanol (˜5 ml) was added
3. customto quench
4. customthe reaction
5. customThe solution was evaporated under reduced pressure
6. customthe residue was purified