反应详情

3-(2-Chloropyrimidin-4-yl)-7-(1-methyl-1-triethylsilanyloxyethyl)-imidazo[1,2-α]pyrimidine (from Example 34) (58 mg, 0.14 mmol) and 2-tributylstannylfuran (102 mg, 0.29 mmol) were heated at reflux overnight as described in Example 40. Purification by column chromatography on silica using 70% EtOAc/isohexanes as the eluent gave 3-[2-(furan-2-yl)pyrimidin-4-yl]-7-(1-methyl-1-triethylsilanyloxyethyl)imidazo[1,2-α]pyrimidine (36 mg, 57%): m/z (ES+) 435 (M+H+).

1. temperatureat reflux overnight
2. customPurification by column chromatography on silica using 70% EtOAc/isohexanes as the eluent