反应详情

温度

0 °C

To a cold (0° C.) solution of 1-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-ol (5.00 g. 15.0 mmol) in chloroform (400 mL) was added manganese dioxide (130 g, 1.50 mol). The reaction mixture was stirred at 0° C. for 1.5 hours. The reaction mixture was filtered through a pad of Celite. The filtrate was concentrated in vacuo to provide 1-[2-(4-fluorophenyl)-6-(trifluoromethyl)pyrazolo[1,5-a]pyridin-3-yl]-2-propyn-1-one (3.44 g, 69%) as a clear oil. Rf 0.39 (4:1 hexanes:ethyl acetate); 1H NMR (400 MHz, CDCl3) δ 8.90 (s, 1H), 8.61 (d,1H), 7.72–7.69 (m, 3H), 7.17 (m, 2H), 3.06 (s,1H); MS m/z 333 (M+1).

1. filtrationThe reaction mixture was filtered through a pad of Celite
2. concentrationThe filtrate was concentrated in vacuo