反应详情

To a solution of 6-[(4-acetyl-2,6-dichlorophenyl)amino]pyrido[4,3-c]-1,6-naphthyridin-10(9H)-one (Examples 144 and 145, Step 3) (1.3 g, 3.26 mmol) in THF (30 mL) at 0° C. under nitrogen atmosphere was added methyl magnesium bromide (11.6 mL, 1.4 M in THF/toluene) and the reaction mixture stirred for 30 min. The solution was quenched with 1 N citric acid, diluted with 1:1 THF/EtOAc, and neutralized with saturated NaHCO3. The organic layer was concentrated, triturated with diethyl ether, and filtered to afford the desired product as a yellow powder.

1. customThe solution was quenched with 1 N citric acid
2. additiondiluted with 1:1 THF/EtOAc
3. concentrationThe organic layer was concentrated
4. customtriturated with diethyl ether
5. filtrationfiltered