反应详情

温度

5 °C

To a suspension of 0.30 g of tert-butyl (2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)(1-(2-(7-fluoro-2-oxo-1,5-naphthyridin-1(2H)-yl)ethyl)piperidin-4-yl)carbamate in 2 mL of 2-propanol, 0.23 mL of concentrated hydrochloric acid was added, and the resultant mixture was stirred for 1 hour and 50 minutes under reflux with heating. The reaction mixture was cooled to 5° C., and the solid was obtained by filtration to give 0.28 g of 1-(2-(4-((2,3-dihydro(1,4)dioxino(2,3-c)pyridin-7-ylmethyl)amino)piperidin-1-yl)ethyl)-7-fluoro-1,5-naphthyridin-2(1H)-one trihydrochloride as a light yellow solid.

1. additionwas added
2. temperatureunder reflux
3. temperaturewith heating
4. customthe solid was obtained by filtration