反应详情

温度

-20 °C

Cyclohex-2-enesulfonyl-benzene (7) (10 g, 45 mmol) is dissolved in 450 ml of dry THF and cooled down to −20° C. Then 1.6 M BuLi in Hexane (30.9 ml, 49.5 mmol) is added and stirred for 15 min. After addition of benzyl 2-bromoethylether (8.5 ml, 54 mmol) the mixture is stirred for 1 h at 0° C. Then the mixture is evaporated to dryness. The residue is treated with ice/1M HCl and extracted twice with ether. The combined organic layers are dried over Na2SO4 and evaporated under educed pressure. The product is used in the next step without further purification.

1. stirringis stirred for 1 h at 0° C
2. customThen the mixture is evaporated to dryness
3. additionThe residue is treated with ice/1M HCl
4. extractionextracted twice with ether
5. dry with materialThe combined organic layers are dried over Na2SO4
6. customevaporated under educed pressure
7. customThe product is used in the next step without further purification