反应详情

The title compound was prepared in analogy to Example 70 starting from 4-chloromethyl-1-methanesulfonyl-piperidine (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C23H25ClN2O35: 444, observed (M+H)+: 445.1 1HNMR (400 MHz, DMSO-d6) δppm 1.23-1.41 (m, 2 H) 1.66-1.78 (m, 2 H) 1.84-1.98 (m, 1 H) 2.02 (dd, J=9.09, 4.80 Hz, 1 H) 2.30 (dd, J=7.71, 4.67 Hz, 1 H) 2.67 (t, J=11.75 Hz, 2 H) 2.83 (s, 3 H) 3.11 (t, J=8.46 Hz, 1 H) 3.56 (d, J=12.13 Hz, 2 H) 3.71 (d, J=7.33 Hz, 2 H) 6.12 (d, J=7.33 Hz, 1 H) 6.66-6.80 (m, 1 H) 7.10-7.20 (m, 2 H) 7.25-7.34 (m, 2 H) 7.34-7.43 (m, 2 H).