反应详情

The title compound was prepared in analogy to Example 101 starting from methyl-3-bromo-5-(2-oxooxazolidin-3-yl)benzoate prepared as in Example 101, 4-methylene-tetrahydro-pyran, isatin (commercially available) according to Scheme 2. LC/MS m/e calcd. for C24H22N206: 434, observed (M+H)+: 434.21H NMR (400 MHz, DMSO-d6) δppm 1.72-1.80 (m, 1 H) 1.83 (d, J=4.29 Hz, 1 H) 1.91-2.01 (m, 3 H) 2.06-2.16 (m, 1 H) 3.36-3.44 (m, 1 H) 3.50-3.56 (m, 1 H) 3.58-3.65 (m, 2 H) 4.13-4.21 (m, 2 H) 4.48 (t, J=7.96 Hz, 2 H) 6.90 (d, J=8.08 Hz, 1 H) 7.07 (t, 1 H) 7.23 (t, 1 H) 7.29 (d, J=7.58 Hz, 1 H) 7.71 (s, 1H) 7.92 (s, 1 H) 8.19 (s, 1 H) 13.40 (s, 1 H).