反应详情

The title compound was prepared in analogy to Example 81 starting from dibromo ethylene, 1-(pyridin-4-yl)piperazine (commercially available), (1R,2S) and (1S,2R)-2-(4-chlorophenyl)spiro[cyclopropane-1,3′-indolin]-2′-one prepared as in Scheme 1. LC/MS m/e calcd. for C27H27ClN4O: 458, observed (M+H)+: 459.2 1HNMR (400 MHz, MeOD-d4) δppm 1.32 (s, 2 H) 2.02-2.40 (m, 3 H) 3.26 (s, 1 H) 3.47 (d, J=9.09 Hz, 8 H) 4.02 (br. s., 4 H) 4.25 (s, 2 H) 6.11 (d, J=7.33 Hz, 1 H) 6.80 (s, 1 H) 7.12-7.18 (m, 1 H) 7.19-7.27 (m, 3 H) 7.32 (t, J=8.97 Hz, 4 H) 8.27 (d, J=7.83 Hz, 2 H).