反应详情

As described for example 31e, 6-[5-methyl-3-(tetrahydro-pyran-4-yl)-isoxazol-4-ylmethoxy]-nicotinic acid methyl ester (100 mg, 0.3 mol), instead of 6-(3-cyclohexyl-5-methyl-isoxazol-4-ylmethoxy)-nicotinic acid methyl ester was converted, to the title compound (80 mg, 74%) which was obtained as a white solid after purification by chromatography (silica, 30 to 70% ethyl acetate in heptane). MS: m/e=360.3 [M+H]+.